Dissolution studies of agomelatine-coated microneedles for potential use in transdermal drug delivery
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0000-0002-2672-6171 Date
2023-09-23
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Heinrich Heine University Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics
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Abstract
INTRODUCTION Microneedles are small devices that puncture the skin and deliver the active pharmaceutical ingredient into the bloodstream by increasing skin penetration and bypassing the stratum corneum barrier. The transdermal route of drug delivery, using microneedle systems, could be a chance to improve the bioavailability of rapidly metabolized drugs. Agomelatine, an antidepressant, is characterized by poor bioavailability after oral administration due to the hepatic first-pass effect. Employing microneedles may improve its bioavailability and increase the effectiveness of antidepressant therapy. The aim of this research was to assess if various gel coatings, microneedle geometries, and 3D-printing methods influence the dissolution rate from 3D-printed microneedle systems. MATERIAL AND METHODS Microneedle systems with various geometries like pyramids and spearheads were printed using two different 3D-printing methods: Fused Filament Fabrication and Digital Light Processing. Printed devices were dip-coated with previously prepared gels containing agomelatine. The drug release from prepared samples was assessed using Franz diffusion cells and the phosphate buffer. Additionally, for selected samples, ex vivo permeation studies were performed on human cadaver skin. RESULTS AND DISCUSSION A 3D-printing is an emerging technology allowing for the creation of potential medical devices tailored to one’s needs. Various methods and materials used for printing, as well as the parameters, such as the shape of the needles, may affect the coating process and lead to differences in dissolution profiles. In this study, two types of gels used to coat microneedles presented different mechanical properties which affected the coating process. Also, the gels varied regarding the method of drug-loading. In one gel, substance was dissolved, while in another gel, suspended. The acceptor medium to which the coating was dissolved and any modifications introduced to this medium also have an impact on release studies
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This repository contains the conference abstract related to the presentation entitled “Dissolution studies of agomelatine-coated microneedles for potential use in transdermal drug delivery”, presented during the 10th Polish-German Symposium on Pharmaceutical Sciences — PolGerSym10: “Beyond Corona – Shaping the future”, held on 22–23 September 2023 at Heinrich Heine University Düsseldorf, Germany.
The work focused on the influence of microneedle geometry, 3D-printing method and gel coating type on agomelatine release, as well as selected ex vivo permeation studies using human cadaver skin.
The conference material is associated with the project “3D printing as a tool for obtaining transdermal microneedle systems with increased effectiveness in the treatment of depressive disorders”, grant no. UMO-2021/42/E/NZ7/00125, funded by the National Science Centre, Poland.
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Wojtyłko M, Michniak-Kohn BB, Lamprou DA, Budnik I, Froelich A, Kordyl O, Jadach B, Kuczko W, Wichniarek R, Nowicka A, Szybowicz M, Krysztofiak J, Białek A, Osmałek T. Dissolution studies of agomelatine-coated microneedles for potential use in transdermal drug delivery. In: Book of Abstracts: 10th Polish-German Symposium on Pharmaceutical Sciences — PolGerSym10: “Beyond Corona – Shaping the future”; 22–23 September 2023; Düsseldorf, Germany. Heinrich Heine University Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics; 2023.