Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp2)–H Functionalization

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Authors
Brześkiewicz, Jakub
Loska, Rafał
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
License
Creative Commons License
Creative Commons Attribution 4.0 International License
Abstract
The palladium-catalyzed C(sp2)–H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds.
Description
Keywords
aAromatic compounds    cyclization    functionalization    hydrocarbons    nitrogen compounds
Citation
Org. Lett. 2022, 24, 22, 3960–3964 ; https://doi.org/10.1021/acs.orglett.2c01317
URI
https://open.icm.edu.pl/handle/123456789/21767
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