Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp2)–H Functionalization

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dc.contributor.authorBrześkiewicz, Jakub
dc.contributor.authorLoska, Rafał
dc.contributor.organizationInstitute of Organic Chemistry, Polish Academy of Sciencesen
dc.date.accessioned2022-10-21T13:54:18Z
dc.date.available2022-10-21T13:54:18Z
dc.date.issued2022
dc.description.abstractThe palladium-catalyzed C(sp2)–H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds.en
dc.description.sponsorshipNational Science Centre SONATA BIS 7 Grant (UMO-2017/26/E/ST5/00388); National Science Centre PRELUDIUM 19 Grant (Grant UMO-2020/37/N/ST4/00777); Ministry of Science and Education, Poland, DIAMENTOWY GRANT VIII Program (Grant 0235/DIA/2019/48)
dc.identifier.citationOrg. Lett. 2022, 24, 22, 3960–3964 ; https://doi.org/10.1021/acs.orglett.2c01317en
dc.identifier.doi10.1021/acs.orglett.2c01317
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/21767
dc.language.isoen
dc.publisherAmerican Chemical Societyen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectaAromatic compoundsen
dc.subjectcyclizationen
dc.subjectfunctionalizationen
dc.subjecthydrocarbonsen
dc.subjectnitrogen compoundsen
dc.titlePalladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp2)–H Functionalizationen
dc.typearticleen
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