The role of the Notch signaling pathway in rhabdomyosarcomas

Thumbnail Image
EJTCM_2025_8_1_Kalali.pdf (515.78 KB)
Authors
Kalali, Datis ORCID logo 0000-0002-7345-1692
Milošević, Emilija ORCID logo 0000-0002-0026-1871
Anestakis, Doxakis ORCID logo 0000-0001-8004-7666
Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
Medical University of Gdansk
License
Creative Commons License
Attribution-ShareAlike 4.0 International
Abstract
Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with poor prognosis in cases of metastasis. Different signal transduction pathways have been studied in RMS cells as to shed some light into the tumorigenesis and metastasis mechanisms of this cancer in the search for new diagnostic and therapeutic strategies. The Notch pathway, which regulates cell survival, is widely studied in different cancers, including sarcomas and its activation has been known to induce cell motility. To this end, the present review explores the role of the Notch signaling pathway in the progression of RMS and in potential therapeutic strategies.
Description
Keywords
rhabdomyosarcoma  pediatric sarcomas  Notch signaling  signal transduction pathways
Citation
Kalali D, Milošević E, Anestakis D. The role of the Notch signaling pathway in rhabdomyosarcomas. Eur J Transl Clin Med. 2025;8(1):97-102
URI
https://open.icm.edu.pl/handle/123456789/26032
Related research dataset
Belongs to collection
Artykuły / Articles