Diffusion in crowded biological environments: applications of Brownian dynamics

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dc.contributor.authorDługosz, Maciej
dc.contributor.authorTrylska, Joanna
dc.contributor.organizationInterdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego, Uniwersytet Warszawskipl_PL
dc.date.accessioned2011-07-05T10:00:44Z
dc.date.available2011-07-05T10:00:44Z
dc.date.issued2011-03-02
dc.description.abstractBiochemical reactions in living systems occur in complex, heterogeneous media with total concentrations of macromolecules in the range of 50 - 400 mg/ml. Molecular species occupy a significant fraction of the immersing medium, up to 40% of volume. Such complex and volume-occupied environments are generally termed 'crowded' and/or 'confined'. In crowded conditions non-specific interactions between macromolecules may hinder diffusion - a major process determining metabolism, transport, and signaling. Also, the crowded media can alter, both qualitatively and quantitatively, the reactions in vivo in comparison with their in vitro counterparts. This review focuses on recent developments in particle-based Brownian dynamics algorithms, their applications to model diffusive transport in crowded systems, and their abilities to reproduce and predict the behavior of macromolecules under in vivo conditions.en
dc.description.epersonBartosz Brach
dc.description.sponsorshipThe authors acknowledge support from University of Warsaw (BST 2010, G31-4), Polish Ministry of Science and Higher Education (N N301 245236, N N519 646640) and Foundation for Polish Science (Focus program and TEAM/2009-3/8 project co-financed by European Regional Development Fund operated within Innovative Economy Operational Programme).en
dc.identifier.citationDługosz and Trylska: Diffusion in crowded biologicalenvironments: applications of Brownian dynamics. BMC Biophysics 2011, 4:3
dc.identifier.issn2046-1682
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/75
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsUznanie autorstwa 3.0 Polskapl_PL
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/
dc.titleDiffusion in crowded biological environments: applications of Brownian dynamicsen
dc.typearticleen
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