Multiwavelength laser doppler holography (MLDH) in spatiotemporal optical coherence tomography (STOC-T) for human retinal blood flow visualization in vivo

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dc.contributor.authorBorycki, Dawid
dc.contributor.authorAuksorius, Egidijus
dc.contributor.authorWęgrzyn, Piotr
dc.contributor.authorLiżewski, Kamil
dc.contributor.authorTomczewski, Sławomir
dc.contributor.authorŽičkienė, Ieva
dc.contributor.authorAdomavičius, Karolis
dc.contributor.authorKarnowski, Karol
dc.contributor.authorWojtkowski, Maciej
dc.contributor.organizationInternational Centre for Translational Eye Research, Warsaw, Poland
dc.contributor.organizationInstitute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
dc.contributor.organizationCenter for Physical Sciences and Technology (FTMC), Vilnius, Lithuania
dc.contributor.organizationFaculty of Physics, University of Warsaw, Warsaw, Poland
dc.date.accessioned2025-03-17T15:20:07Z
dc.date.available2025-03-17T15:20:07Z
dc.date.issued2024-03-12
dc.description.abstractSpatiotemporal optical coherence tomography (STOC-T) is the new modality for high-speed, crosstalk- and aberration-free volumetric imaging of biological tissue in vivo. STOC-T extends the Fourier-Domain Full-Field Optical Coherence Tomography (FD-FF-OCT) by the spatial phase modulation that enables reduction of spatial coherence of the tunable laser, which suppresses coherent noise, and consequently, improves the imaging depth. Furthermore, the geometrical aberrations are removed computationally in postprocessing. We recently demonstrated high-speed, high-resolution STOC-T of the human eye in vivo. Here, we show that the dataset produced by STOC-T can be processed differently to reveal blood flow in the superficial and deep retina layers. To render the blood flow, we estimated the spectral broadening to intrinsic sample motion. This approach enables us to access the approximated information about the Doppler-shifted optical field backscattered from the sample. This novel approach enables us to access the approximated information about the Doppler-shifted optical field backscattered from the sample and analyze it using methods from the Laser Doppler Holography (LDH). By doing so, we can render the blood flow images from a single volume. Our method, denoted as multiwavelength laser Doppler holography (MLDH) links LDH and laser Doppler flowmetry with the multiwavelength holographic tomography to enable noninvasive visualization and quantification of the blood flow deep into the human retina at high speeds and high transverse resolution in vivo.en
dc.description.sponsorshipNarodowe Centrum Nauki (NCN, 2016/22/A/ST2/00313, 2020/38/L/ST2/00556); Fundacja na Rzecz Nauki Polskiej: International Centre for Translational Eye Research (MAB/2019/12); Horizon 2020 Framework Programme (666295); Lietuvos Mokslo Taryba (01.2.2-LMT-K-718-03-0093 and P-LL-21-100). K. Karnowski acknowledges the support from the Polish National Agency for Academic Exchange (PPN/PPO/2018/1/00082).
dc.identifier.citationDawid Borycki, Egidijus Auksorius, Piotr Węgrzyn, Kamil Liżewski, Sławomir Tomczewski, Ieva Žičkienė, Karolis Adomavičius, Karol Karnowski, Maciej Wojtkowski, Multiwavelength laser doppler holography (MLDH) in spatiotemporal optical coherence tomography (STOC-T), Biocybernetics and Biomedical Engineering, 44 , 264-275 (2024). https://doi.org/10.1016/j.bbe.2024.03.002
dc.identifier.doi10.1016/j.bbe.2024.03.002
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/25538
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofseries44
dc.rightsUznanie autorstwa 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceBiocybernetics and Biomedical Engineering
dc.subjectoptical coherence tomographyen
dc.subjectDoppler flowmetryen
dc.subjectlaser doppler holographyen
dc.subjectFourier-domainen
dc.titleMultiwavelength laser doppler holography (MLDH) in spatiotemporal optical coherence tomography (STOC-T) for human retinal blood flow visualization in vivoen
dc.typearticle
dc.type.versionsubmittedVersion
person.identifier.orcidBorycki, Dawid [0000-0002-1235-889X]
person.identifier.orcidAuksorius, Egidijus [0000-0002-3742-067X]
person.identifier.orcidWęgrzyn, Piotr [0000-0002-3269-6722]
person.identifier.orcidLiżewski, Kamil [0000-0002-3350-4622]
person.identifier.orcidTomczewski, Sławomir [0000-0001-7938-2088]
person.identifier.orcidKarnowski, Karol [0000-0002-5426-5878]
person.identifier.orcidWojtkowski, Maciej [0000-0003-0599-0878]
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