Redox behaviour of Cu-Aβ(4-16) complexes related to Alzheimer's Disease

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dc.contributor.authorWiloch, Magdalena
dc.contributor.authorLinfield, Steven
dc.contributor.authorBaran, Natalia
dc.contributor.authorNogala, Wojciech
dc.contributor.authorJönsson-Niedziółka, Martin
dc.contributor.editorWiloch, Magdalena
dc.contributor.organizationInstitute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Polanden
dc.date.accessioned2024-03-13T15:35:48Z
dc.date.available2024-03-13T15:35:48Z
dc.date.issued2024
dc.description.abstractThe development of Alzheimer’s Disease (AD) has been linked to abnormal quantities of β-amyloid peptides in the brain. The majority of studies have focussed on Aβ(1-40/42) amyloids and their Cu(II)-Aβ(1-40/42) complexes which are responsible for production of reactive oxygen and nitrogen species (ROS and RNS), which are highly toxic to neurons. According to recent studies on amyloid plaques, Aβ(4-42), which is an N-truncated version of Aβ(1-42), is as prevalent as Aβ(1-42) in the brain. Although Cu(II) ions, bounded by Aβ(4-42), can be oxidized to highly reactive Cu(III) ions, its Cu(II) complexes do not appear to contribute to ROS/RNS formation. In this paper, the pH-dependent voltammetric response of Aβ(4-16)-Cu(II) complexes is investigated to understand the influence of the deprotonation of tyrosine within the complex towards the Cu(II)/Cu(III) reaction. The results will help to better understand the scavenging role of tyrosine in quenching highly reactive Cu(III) ions not only in Aβ(4-x)-Cu(II) complexes but also provide clues to the reactive properties of other tyrosine-containing amyloid-metal complexes.  en
dc.description.sponsorshipNational Science Centre Poland
dc.identifier.citationWiloch M, Linfield S, Baran N, Nogala W, Jönsson-Niedziółka M. Redox behaviour of Cu-Aβ(4-16) complexes related to Alzheimer’s Disease. This content is a preprint and has not been peer-reviewed.en
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/24012
dc.language.isoen
dc.relation2021/40/C/ST4/00090.en
dc.rightsAttribution-NoDerivatives 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectvoltammetryen
dc.subjectβ-amyloiden
dc.subjecttyrosineen
dc.subjectcopper complexen
dc.subjectAlzheimer’s diseaseen
dc.titleRedox behaviour of Cu-Aβ(4-16) complexes related to Alzheimer's Diseaseen
dc.typearticleen
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