Exploring the relationship between fetal growth restriction and heart rate variability parameters

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dc.contributor.authorLakhno, Igor Victorovich
dc.contributor.organizationKharkiv National Medical University, Kharkiv, Ukraine
dc.date.accessioned2026-01-23T11:48:27Z
dc.date.available2026-01-23T11:48:27Z
dc.date.issued2025-12-30
dc.date.submitted2026-01-19T15:16:02Zen
dc.description.abstractBackground: Fetal growth restriction (FGR) is a multifactorial disturbance of fetal nutrition with short- and long- -term consequences (e.g. autonomic malfunction and delayed neurological maturation). Fetal heart rate variability (HRV) is critically dependent on autonomic regulation. This study focused on identifying a correlation between neonatal biometry and HRV variables. Material and methods: This was a descriptive cross-sectional study of 48 women at 22-36 weeks of pregnancy. The fetal cardiac signals were obtained from the maternal abdominal wall via non-invasive fetal electrocardiography (NI-FECG). The stress index (SI) was selected for evaluation among all linear HRV variables. Cardiotocographic parameters (short-term variation (STV) and long-term variation (LTV)) were determined, along with cardiographic: AC (acceleration capacity) and DC (deceleration capacity). Results: FGR was detected in 9 women. The fetal growth was appropriate in 31 patients. 8 patients were excluded from the study. The detected variables of HRV in FGR were different, however statistical significance was impossible to determine (small number of cases). A strong linear correlation was detected between all the HRV variables: AC, DC, SI, STV, and LTV. Whereas, AC and DC had significant correlation with the 1-minute Apgar score. Multivariate regression analysis showed a statistically significant correlation of SI with the gestational age at birth. Conclusions: SI could be of use in the advancement of conventional FGR management and has potential for further research.en
dc.identifier.citationLakhno I V. Exploring the relationship between fetal growth restriction and heart rate variability parameters. Eur J Transl Clin Med. 2025;8(2):9-16
dc.identifier.issn2657-3156
dc.identifier.issn10.31373/ejtcm/208820
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/26413
dc.language.isoen
dc.publisherMedical University of Gdańsk
dc.rightsUznanie autorstwa-Na tych samych warunkach 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.sourceEuropean Journal of Translational and Clinical Medicine
dc.subjectfetal growth restrictionen
dc.subjectfetal non-invasive electrocardiographyen
dc.subjectheart rate variabilityen
dc.titleExploring the relationship between fetal growth restriction and heart rate variability parametersen
dc.typearticle
dc.type.versionpublishedVersion
person.identifier.orcidLakhno, Igor Victorovich [0000-0002-7914-7296]
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