Toward Coordination Cages with Hybrid Chirality: Amino Acid-Induced Chirality on Metal Centers

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dc.contributor.authorGrajda, Marcin
dc.contributor.authorStaros, Grzegorz
dc.contributor.authorJędrzejewska, Hanna
dc.contributor.authorSzumna, Agnieszka
dc.contributor.organizationInstitute of Organic Chemistry, Polish Academy of Sciencesen
dc.date.accessioned2022-09-14T12:14:13Z
dc.date.available2022-09-14T12:14:13Z
dc.date.issued2022
dc.description.abstractTripodal chiral ligands containing amino acid residues and salicyl-acylhydrazone units were synthesized and used to obtain coordination cages through deprotonation and coordination to gallium. These coordination cages have Ga3L2 stoichiometry and pinwheel geometry with two types of chiral centers built into their walls: stereogenic centers at the amino acid backbones and stereoselectively induced centers at metal ions. The pinwheel geometry is unique among analogous cages and originates from the partial flexibility of the ligands. Despite the flexibility, the ligands induce the chirality of metal centers in a highly stereoselective way, leading to the formation of cages that are single diastereoisomers. It has also been demonstrated that stereoselectivity is a unique feature of cage geometry and leads to effective chiral self-sorting: homochiral cages can be obtained selectively from the mixtures of racemic ligands. The configuration of metal centers was determined by circular dichroism, TD DFT calculation, and X-ray crystallography.en
dc.description.sponsorshipNational Science Center, Poland (PRELUDIUM 2018/29/N/ST5/01348 and OPUS 2017/25/B/ST5/01011) Wroclaw Centre for Networking and Supercomputing (grant no. 299)
dc.identifier.citationInorg. Chem. 2022, 61, 29, 11410–11418 ; https://doi.org/10.1021/acs.inorgchem.2c01738en
dc.identifier.doi10.1021/acs.inorgchem.2c01738
dc.identifier.issn0020-1669
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/21627
dc.language.isoen
dc.publisherAmerican Chemical Societyen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleToward Coordination Cages with Hybrid Chirality: Amino Acid-Induced Chirality on Metal Centersen
dc.typearticleen
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