Advances in understanding, diagnosis and targeting ATTR cardiomyopathy: a review

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dc.contributor.authorKulak, Maria
dc.contributor.authorLang, Miriam
dc.contributor.authorLange, Natalia
dc.contributor.organizationFaculty of Medicine, Medical University of Gdańsk, Poland
dc.contributor.organizationLower Silesian Oncology Center, Wrocław, Poland
dc.contributor.organizationOrthopedic Clinic Rehasport, Gdańsk, Poland
dc.contributor.organizationT. Marciniak Memorial Lower Silesian Specialist Hospital, Wrocław, Poland
dc.date.accessioned2024-07-02T13:41:59Z
dc.date.available2024-07-02T13:41:59Z
dc.date.issued2024-06-28
dc.description.abstractTransthyretin amyloidosis (ATTR) manifests as wild-type (ATTRwt) and hereditary/mutant (ATTRv) forms and can lead to heart failure due to cardiac amyloidopathy. Diagnosing ATTR, particularly in asymptomatic carriers of pathogenic variants, remains challenging despite the advances. Complex and multi-aspect management involves a limited range of well-examined conventional therapies to address the heart failure and frequently coexisting arrhythmias and valvular issues. Disease-modifying treatment, RNA-based treatments, CRISPR-Cas9 gene editing and monoclonal antibodies targeting amyloid deposits are recent and promising innovations. This review explores the diagnostic intricacies, therapeutic dilemmas and emerging solutions in ATTR cardiomyopathy. The significance of early detection and precise, targeted approaches to enhance patient outcomes is underscored.en
dc.identifier.citationKulak M., Lang M., Wiśniewski M., Lange N. Advances in understanding, diagnosis and targeting ATTR cardiomyopathy: a review Eur J Transl Clin Med 2024;7(1):63-78. DOI: 10.31373/ejtcm/189121
dc.identifier.doi10.31373/ejtcm/189121
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/24573
dc.language.isoen
dc.publisherMedical University of Gdańsk
dc.rightsUznanie autorstwa-Na tych samych warunkach 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.sourceEuropean Journal of Translational and Clinical Medicine
dc.subjectcardiomyopathyen
dc.subjectamyloidosisen
dc.subjecttransthyretinen
dc.titleAdvances in understanding, diagnosis and targeting ATTR cardiomyopathy: a review
dc.typearticle
dc.type.versionpublishedVersion
person.identifier.orcidLang, Miriam [0009-0002-5226-1467]
person.identifier.orcidLange, Natalia [0000-0002-1710-4637]
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