Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

Simple item record

Full item record

dc.contributor.authorWeber, Philipp
dc.contributor.authorCai, Ling
dc.contributor.authorAguilar Rojas, Francisco Javier
dc.contributor.authorGarciamendez‐Mijares, Carlos Ezio
dc.contributor.authorTirelli, Maria Celeste
dc.contributor.authorNalin, Francesco
dc.contributor.authorJaroszewicz, Jakub
dc.contributor.authorŚwięszkowski, Wojciech
dc.contributor.authorCostantini, Marco
dc.contributor.authorZhang, Yu Shrike
dc.contributor.organizationDivision of Engineering in Medicine, Departmentof Medicine, Brigham and Women’s Hospital,Harvard Medical School, Cambridge, Massachusetts, USAen
dc.contributor.organizationInstitute of Physical Chemistry, Polish Academy of Sciencesen
dc.contributor.organizationBiomaterials Group, Materials Design Division,Faculty of Materials Science and Engineering, Warsaw University of Technology, Polanden
dc.date.accessioned2023-12-08T17:17:28Z
dc.date.available2023-12-08T17:17:28Z
dc.date.issued2023-08-29
dc.description.abstractThree-dimensional (3D) printing is an emerging technique that has shown promising success in engineering human tissues in recent years. Further development of vat-photopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and components. Similarly, the development of microfluidic chip systems is an emerging research sector with promising medical applications. This work demonstrates the coupling of a digital light processing (DLP) printing procedure with a microfluidic chip system to produce size-tunable, 3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl (GelMA) hydrogel matrix. It is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high precision. Furthermore, the porosities are printed in two-dimensional (2D) as well as in 3D using the DLP printer. In addition, the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts, where high cell viabilities as well as cell proliferation, spreading, and migration are confirmed. It is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine, among others.en
dc.identifier.citationWeber, P., Cai, L., Rojas, F. J. A., Garciamendez-Mijares, C. E., Tirelli, M. C., Nalin, F., Jaroszewicz, J., Święszkowski, W., Costantini, M., Zhang, Y. S., Aggregate 2023, 00, e409. https://doi.org/10.1002/agt2.409en
dc.identifier.doi10.1002/agt2.409
dc.identifier.issn2692-4560
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/23316
dc.language.isoen
dc.publisherWileyen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject3D printingen
dc.subjectbiofabricationen
dc.subjectbubbleen
dc.subjectdigital light processingen
dc.subjectmicrofluidicsen
dc.subjectporousen
dc.titleMicrofluidic bubble-generator enables digital light processing 3D printing of porous structuresen
dc.typearticleen
Files for this record
Original bundle
Now showing 1 - 1 of 1
Name: Microfluidic bubble-generator enables digital light processing 3D - Aggregate - 2023 - Weber.pdf
Size: 5.61 MB
Format: Adobe Portable Document Format
Description:
Download
License files
Name: license.txt
Size: 236 B
Format: Plain Text
Description:
Download
Belongs to collection
Artykuły ICHF PAN / IPC PAS Articles