Predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients.

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dc.contributor.authorSingh, Kuldeep
dc.contributor.authorYadav, Amlendu
dc.contributor.authorYadav, Rupesh
dc.contributor.authorSeshi Kumar, Damera
dc.contributor.authorPurohit, Ankit
dc.contributor.authorDahiya, Komal
dc.contributor.authorKumar, Praveen
dc.contributor.organizationDepartment of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India
dc.contributor.organizationDepartment of Anesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India
dc.contributor.organizationDepartment of Critical Care and Emergency Medicine, Sir Gangaram Hospital, New Delhi, India
dc.contributor.organizationDr. Ram Manohar Lohia Hospital
dc.date.accessioned2024-07-02T11:20:50Z
dc.date.available2024-07-02T11:20:50Z
dc.date.issued2024-06-30
dc.description.abstractINTRODUCTION: Vitamin D and HDL (high density lipoprotein) levels have potential to be used as an early and simple predictor of morbidity and mortality in critically ill patients. The aim of the study was to determine the predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients. MATERIALS AND METHODS: Prospective observational study involving 302 patients admitted to an intensive care unit (ICU). Blood samples were obtained within the initial 24 hours of admission to assess vitamin D and HDL levels. Vitamin D levels of >20 ng/ml were considered non-deficient and ≤ 20 ng/mL considered deficient. HDL levels >30 mg/dl were considered normal HDL and <30 mg / dl were considered low HDL. The study collected data on various parameters including the APACHE II score at the ICU admission, SOFA scores throughout the ICU stay, 28-day mortality, as well as the requirement for mechanical ventilation, inotropic support, and renal replacement therapy RESULTS: Of 302 patients, 102 (33.77%) had mortality in 28 days. While analysing the predictive capacity of vitamin D and HDL alone and in combination for mortality at 28 days, the AUC (Area Under the Curve) was 0.667 (95% CI 0.610 TO 0.720), 0.673 (95%CI 0.617 TO 0.725), 0.628 (95% CI 0.571 TO 0.683) respectively. The vitamin D level 12 ng/ml and the HDL level 29 mg/dl were found to have a statistically significant association with mortality. P value <0.001. CONCLUSIONS: The study showed that vitamin D and HDL levels alone and in combination have a significant association with mortality in critically ill patients.en
dc.identifier.citationSingh K, Yadav A, Yadav R, Kumar DS, Purohit A, Dahiya K, Kumar P. Predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients. Crit. Care Innov. 2024; 7(2): 1-11.
dc.identifier.doi10.32114/CCI.2024.7.2.1.11
dc.identifier.issn2545-2533
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/24555
dc.language.isoen
dc.publisherTowarzystwo Pomocy Doraźnej
dc.rightsUznanie autorstwa-Użycie niekomercyjne 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceCritical Care Innovations
dc.subjectintensive care uniten
dc.subjecthigh-density lipoproteinen
dc.subjectmortalityen
dc.subjectvitamin Den
dc.titlePredictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients.en
dc.typearticle
dc.type.versionupdatedVersion
person.identifier.orcidSingh, Kuldeep [0000-0003-3960-7179]
person.identifier.orcidSeshi Kumar, Damera [0000-0003-3439-2244]
person.identifier.orcidYadav, Rupesh [0000-0002-6379-6101]
person.identifier.orcidYadav, Amlendu [0000-0003-3671-1587]
person.identifier.orcidPurohit, Ankit [0009-0007-6222-0016]
person.identifier.orcidDahiya, Komal [0009-0006-1620-8449]
person.identifier.orcidKumar, Praveen [0009-0005-6432-6397]
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