H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters

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dc.contributor.authorNiedbała, Patryk
dc.contributor.authorMajdecki, Maciej
dc.contributor.authorGrodek, Piotr
dc.contributor.authorJurczak, Janusz
dc.contributor.organizationInstitute of Organic Chemistry, Polish Academy of Sciencesen
dc.date.accessioned2022-06-24T12:20:34Z
dc.date.available2022-06-24T12:20:34Z
dc.date.issued2022
dc.description.abstractIn this work, we would like to present the development of a highly optimized method for generating the quaternary stereogenic centers in β-keto esters. This enantioselective phase-transfer alkylation catalyzed by hybrid Cinchona catalysts allows for the efficient generation of the optically active products with excellent enantioselectivity, using only 1 mol% of the catalyst. The vast majority of phase-transfer catalysts in asymmetric synthesis work by creating ionic pairs with the nucleophile-attacking anionic substrate. Therefore, it is a sensible approach to search for new methodologies capable of introducing functional groups into the precursor’s structure, maintaining high yields and enantiomeric purity.en
dc.description.sponsorshipNational Science Center, Poland (grant: 2018/29/B/ST5/01366)
dc.identifier.citationNiedbała, P.; Majdecki, M.;Grodek, P.; Jurczak, J. H-Bond Mediated Phase-Transfer Catalysis: Eantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters. Molecules 2022, 27, 2508. https://doi.org/10.3390/molecules27082508en
dc.identifier.doi10.3390/molecules27082508
dc.identifier.issn1420-3049
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/21379
dc.language.isoen
dc.publisherMDPIen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectphase-transfer catalysisen
dc.subjectorganocatalysisen
dc.subjectenantioselectivityen
dc.subjectCinchona catalystsen
dc.subjectalkylationen
dc.titleH-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Estersen
dc.typearticleen
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