The impact of renal function on clinical and biochemical characteristics in advanced heart failure patients

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dc.contributor.authorBohdan, Michał
dc.contributor.authorFrankiewicz, Anna
dc.contributor.authorGruchała, Marcin
dc.contributor.organizationFirst Department of Cardiology, Medical University of Gdansken
dc.contributor.organizationClinical Centre of Cardiology, University Clinical Centre, Gdansken
dc.date.accessioned2019-08-21T13:13:18Z
dc.date.available2019-08-21T13:13:18Z
dc.date.issued2018
dc.description.abstractBackground Coexistence of heart failure with reduced ejection fraction (HFrEF) and chronic kidney disease is associated with poor prognosis. We assessed the effect of renal function on exercise capacity and clinical parameters in patients with HFrEF. Material and methods Forty five patients aged 58.2 ± 10.6 years with stable severe HFrEF were recruited. Patients were divided into 3 groups: group 1 - eGFR: 30-59 ml/min/1.73 m2; group 2 - eGFR: 60-89 ml/min/1.73 m2 and group 3 - eGFR: ≥90 ml/min/1.73 m2. Biochemical analysis, echocardiography, six-minute walking test and cardiopulmonary stress testing were performed. Results Patients in group 1 were significantly older than patients in group 3 (60.4 ± 11.1 years vs. 49.25 ± 11.2 years, rescpectively, p<0.05). Patients in group 2 had significantly higher BMI in comparison to group 3 (29.8 ± 4.4 vs. 25.1 ± 4.2; p<0.05). Interestingly, patients in group 1 had significantly lower peak oxygen uptake (10.2 ± 3.1 ml/kg/min vs. 16.1 ± 3.5 ml/kg/min, p<0.05) and oxygen uptake at anaerobic treshold (7.9 ± 2.4 ml/kg/min vs. 10.7 ± 1.9 ml/kg/min, p<0.05). Conclusions Diminished renal function in patients with stable, advanced HFrEF may be associated with significantly worse peak VO2 and VO2 in AT.en
dc.identifier.citationBohdan M, Frankiewicz A, Gruchała M. The impact of renal function on clinical and biochemical characteristics in advanced heart failure patients. Eur J Transl Clin Med. 2018;1(2):17-22. DOI: 10.31373/ejtcm/102804en
dc.identifier.doi10.31373/ejtcm/102804
dc.identifier.issn2657-3156
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/17217
dc.language.isoen
dc.publisherGdański Uniwersytet Medycznyen
dc.rightsUznanie autorstwa-Na tych samych warunkach 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/pl/*
dc.subjectheart failureen
dc.subjectkidney diseaseen
dc.subjectexercise capacityen
dc.titleThe impact of renal function on clinical and biochemical characteristics in advanced heart failure patientsen
dc.typearticleen
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