Genetic variation of two horse breeds in CpG islands of OAS1 locus

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dc.contributor.authorZąbek, Tomasz
dc.contributor.authorSemik, Ewelina
dc.contributor.authorFornal, Agnieszka
dc.contributor.authorBugno-Poniewierska, Monika
dc.contributor.organizationLaboratory of Genomics, National Research Institute of Animal Production, Balice, Polandpl_PL
dc.contributor.organizationDepartment of Cytogenetics and Molecular Genetics, National Research Institute of Animal Production, Balice, Polandpl_PL
dc.date.accessioned2015-03-03T20:32:49Z
dc.date.available2015-03-03T20:32:49Z
dc.date.issued2014-11-15
dc.description.abstractAllelic and haplotypic variations at 27 SNP sites identified in four CpG islands of OAS1 were described in a group of Anglo-Arabian and Hucul horses. Variation in the type of less frequent alleles was the source of variability among breeds. A number of putative LD blocks were identified which could be used to study changes in the genetic structure between generations of both breeds concerning susceptibility to flaviviral infections. Some of the identified SNPs may have an impact on the transcriptional activity of OAS1 or could lead to amino acid substitution influencing proper function of OAS1 enzyme. In the light of recent studies, the described genetic variability of investigated CpG islands might be important in view of the effectiveness of viral incorporation into the host genome.pl_PL
dc.description.epersonAgnieszka Fornal
dc.description.sponsorshipN N311 539340.pl_PL
dc.identifier.citationZąbek, T., Semik, E., Fornal, A., Bugno-Poniewierska, M. (2014). Genetic variation of two horse breeds in CpG islands of OAS1 locus. Annals of Animal Science, 14(4), 841-850.pl_PL
dc.identifier.doi10.2478/aoas-2014-0069
dc.identifier.issn1642-3402
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/6406
dc.language.isoenpl_PL
dc.publisherInstytut Zootechnikipl_PL
dc.rightsUznanie autorstwa-Na tych samych warunkach 3.0 Polska
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/pl/
dc.subjecthorsespl_PL
dc.subjectCpG islandspl_PL
dc.subjectgenetic variationpl_PL
dc.subjectOAS1pl_PL
dc.subjectSNPpl_PL
dc.titleGenetic variation of two horse breeds in CpG islands of OAS1 locuspl_PL
dc.typearticlepl_PL
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