Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves

Simple item record

Full item record

dc.contributor.authorSip, Szymon
dc.contributor.authorGościniak, Anna
dc.contributor.authorSzulc, Piotr
dc.contributor.authorWalkowiak, Jarosław
dc.contributor.authorCielecka-Piontek, Judyta
dc.contributor.organizationDepartment of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, Polanden
dc.contributor.organizationDepartment of Agronomy, Poznań University of Life Sciences, Polanden
dc.contributor.organizationDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Polanden
dc.date.accessioned2023-07-21T11:54:07Z
dc.date.available2023-07-21T11:54:07Z
dc.date.issued2022-11-16
dc.description.abstractFive varieties of Actinidia leaves (Geneva, Jumbo, Ken's Red, Kijivska Hibridna, and Sentyabraskaya) were analyzed. The profiles of active compounds were determined, namely quercetin, rutin, epicatechin, chlorogenic acid, and kaempferol, in the raw material. Suspecting that the raw material might prove important in the treatment of diabetes, the authors assessed the antioxidant activity and the ability to inhibit enzymes responsible for the development of diabetes (α-glucosidase and α-amylase). As a result of the conducted analysis, the Ken's Red variety was indicated as having the highest biological activity (DPPH IC50 = 0.332 ± 0.048; FRAP IC0.5 = 0.064 ± 0.005; α-glucosidase inhibition IC50 = 0.098 ± 0.007; α-amylase inhibition IC50 = 0.083 ± 0.004). In order to increase the efficiency of the extraction of active compounds from Ken's Red variety leaves, cyclodextrins (α-CD, β-CD, and γ-CD) were used as extraction process enhancers. The obtained results showed a significant increase in the contents of extracted active compounds. In addition, the type of CD used enhanced the extraction of selected compounds (quercetin, kaempferol, rutin, chlorogenic acid, and epicatechin. This study shows that the application of cyclodextrin-based extraction significantly improved the leaf activity of the Ken's Red variety (DPPH IC50 = 0.160 ± 0.019; FRAP IC0.5 = 0.008 ± 0.001; α-glucosidase inhibition IC50 = 0.040 ± 0.002; α-amylase inhibition IC50 = 0.012 ± 0.003)en
dc.description.sponsorshipNarodowe Centrum Nauki
dc.identifier.citationSip, S.; Gościniak, A.; Szulc, P.; Walkowiak, J.; Cielecka-Piontek, J. Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves. Pharmaceutics 2022, 14, 2473. https://doi.org/10.3390/pharmaceutics14112473en
dc.identifier.doi10.3390/pharmaceutics14112473
dc.identifier.issn1999-4923
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/22758
dc.language.isoen
dc.publisherMDPIen
dc.relation2020/39/O/NZ7/03441en
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectActinidiaen
dc.subjectcyclodextrinen
dc.subjectdiabetesen
dc.subjectenzyme inhibitionen
dc.subjectextractionen
dc.subjectkiwien
dc.titleAssisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leavesen
dc.typearticleen
Files for this record
Original bundle
Now showing 1 - 2 of 2
Name: pharmaceutics-14-02473.pdf
Size: 1.58 MB
Format: Adobe Portable Document Format
Description: Artykuł główny
Download
Name: Dane.zip
Size: 409.04 KB
Format: Unknown data format
Description: Wyniki doświadczeń
Download
License files
Name: license.txt
Size: 236 B
Format: Plain Text
Description:
Download
Name: license_rdf
Size: 913 B
Format: RDF serialized in XML
Description:
Download
Belongs to collection
Artykuły / Articles