Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies

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dc.contributor.authorCelikkin, Nehar
dc.contributor.authorPresutti, Dario
dc.contributor.authorMaiullari, Fabio
dc.contributor.authorFornetti, Ersilia
dc.contributor.authorAgarwal, Tarun
dc.contributor.authorParadiso, Alessia
dc.contributor.authorVolpi, Marina
dc.contributor.authorŚwięszkowski, Wojciech
dc.contributor.authorBearzi, Claudia
dc.contributor.authorBarbetta, Andrea
dc.contributor.authorZhang, Yu Shrike
dc.contributor.authorGargioli, Cesare
dc.contributor.authorRizzi, Roberto
dc.contributor.authorCostantini, Marco
dc.contributor.organizationInstitute of Physical Chemistry, Polish Academy of Sciencesen
dc.contributor.organizationIstituto Nazionale Genetica Molecolare INGM “Romeo Ed Enrica Invernizzi”, Milan, Italyen
dc.contributor.organizationDepartment of Biology, Rome University Tor Vergata, Rome, Italyen
dc.contributor.organizationDepartment of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, Indiaen
dc.contributor.organizationFaculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Polanden
dc.contributor.organizationInstitute of Genetic and Biomedical Research, National Research Council of Italy (IRGB-CNR), Milan, Italyen
dc.contributor.organizationDepartment of Chemistry, Sapienza University of Rome, Rome, Italyen
dc.contributor.organizationDivision of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Cambridge, MA, United Statesen
dc.contributor.organizationInstitute of Biomedical Technologies, National Research Council of Italy (ITB-CNR), Milan, Italyen
dc.date.accessioned2023-12-14T14:53:28Z
dc.date.available2023-12-14T14:53:28Z
dc.date.issued2021-09-16
dc.description.abstractIn the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nevertheless, technological advances are among the main factors which have enabled such progress. In this review, we discuss the contribution of two state-of-the-art technologies–namely biofabrication and organ-on-a-chip–in a selection of biomedical research areas. We start by providing an overview of these technologies and their capacities in fabricating advanced in vitro tissue/organ models. We then analyze their impact on addressing a range of current biomedical challenges. Ultimately, we speculate about their future developments by integrating these technologies with other cutting-edge research fields such as artificial intelligence and big data analysis.en
dc.description.sponsorshipThis study was supported by the National Science Centre—Poland (NCN) within the POLONEZ 3 fellowship number 2016/23/P/NZ1/03604 which has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665778. This study is also supported by the National Science Centre Poland (NCN) within PRELUDIUM 19 Project No. 2020/37/N/ST5/03272 to NC. This work was also supported by the National Science Centre (NCN) under the Grant No.: UMO-2016/23/Z/ST8/04375 (BIOMEMBRANE project (M-ERA.NET2 project 4246)).en
dc.identifier.citationCelikkin N, Presutti D, Maiullari F, Fornetti E, Agarwal T, Paradiso A, Volpi M, Święszkowski W, Bearzi C, Barbetta A, Zhang YS, Gargioli C, Rizzi R and Costantini M (2021) Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies. Front. Bioeng. Biotechnol. 9:732130. doi: 10.3389/fbioe.2021.732130en
dc.identifier.doi10.3389/fbioe.2021.732130
dc.identifier.issn2296-4185
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/23392
dc.language.isoen
dc.publisherFrontiers Mediaen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject3D biofabricationen
dc.subjectorgan-on-a-chipen
dc.subjecttissue engineeringen
dc.subjectregenerative medicineen
dc.subjectprecision medicineen
dc.subjectdrug developmenten
dc.titleTackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologiesen
dc.typearticleen
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