Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
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acs.orglett.2c02320.pdf (2.06 MB)
Date
2022
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American Chemical Society
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Abstract
The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides.
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Citation
Org. Lett. 2022, 24, 5602−5607 ; https://doi.org/10.1021/acs.orglett.2c02320