Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes

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Authors
Potrząsaj, Aleksandra
Ociepa, Michał
Chaładaj, Wojciech
Gryko, Dorota
Date
2022-03-25
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
License
Creative Commons License
Attribution 4.0 International
Abstract
Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we present a bioinspired cobalt catalysis-based strategy to access unprecedented modes of radical reactivity via oxetane ring-opening. This powerful approach gives access to nucleophilic radicals that engage in reactions with SOMOphiles and low-valent transition metals. Importantly, the regioselectivity of these processes complements known methodologies.
Description
Keywords
alkyls  chemical reactions  ethers  organic compounds  ring opening reactions
Citation
Org. Lett. 2022, 24, 2469−2473. https://doi.org/10.1021/acs.orglett.2c00355
URI
https://open.icm.edu.pl/handle/123456789/21367
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