Copper Oxide Electrochemical Deposition to Create Antiviral and Antibacterial Nanocoatings

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dc.contributor.authorKusior, Anna
dc.contributor.authorMazurkow, Julia
dc.contributor.authorJelen, Piotr
dc.contributor.authorBik, Maciej
dc.contributor.authorRaza, Sada
dc.contributor.authorWdowiak, Mateusz
dc.contributor.authorNikiforov, Kostyantyn
dc.contributor.authorPaczesny, Jan
dc.contributor.organizationAGH University of Krakow, Faculty of Material Sciences and Ceramics, Kraków, Poland
dc.contributor.organizationInstitute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
dc.date.accessioned2025-03-06T08:41:36Z
dc.date.available2025-03-06T08:41:36Z
dc.date.issued2024-07-09
dc.description.abstractThe impact of the reaction environment on the formation of the polycrystalline layer and its biomedical (antimicrobial) applications were analyzed in detail. Copper oxide layers were synthesized using an electrodeposition technique, with varying additives influencing the morphology, thickness, and chemical composition. Scanning electron microscopy (SEM) images confirmed the successful formation of polyhedral structures. Unmodified samples (CuL) crystallized as a mixture of copper oxide (I) and (II), with a thickness of approximately 1.74 μm. The inclusion of the nonconductive polymer polyvinylpyrrolidone (PVP) during synthesis led to a regular and compact CuO-rich structure (CuL-PVP). Conversely, adding glucose resulted in forming a Cu2O-rich nanostructured layer (CuL-D(+)G). Both additives significantly reduced the sample thickness to 617 nm for CuL-PVP and 560 nm for CuL-D(+)G. The effectiveness of the synthesized copper oxide layers was demonstrated in their ability to significantly reduce the T4 phage titer by approximately 2.5–3 log. Notably, CuL-PVP and CuL-D(+)G showed a more substantial reduction in the MS2 phage titer, achieving about a 5-log decrease. In terms of antibacterial activity, CuL and CuL-PVP exhibited moderate efficacy against Escherichia coli, whereas CuL-D(+)G reduced the E. coli titer to undetectable levels. All samples induced similar reductions in Staphylococcus aureus titer. The study revealed differential susceptibilities, with Gram-negative bacteria being more vulnerable to CuL-D(+)G due to its unique composition and morphology. The antimicrobial properties were attributed to the redox cycling of Cu ions, which generate ROS, and the mechanical damage caused by nanostructured surfaces. A crucial finding was the impact of surface composition rather than surface morphology on antimicrobial efficacy. Samples with a dominant Cu2O composition exhibited potent antibacterial and antiviral properties, whereas CuO-rich materials showed predominantly enhanced antiviral activity. This research highlights the significance of phase composition in determining the antimicrobial properties of copper oxide layers synthesized through electrodeposition.en
dc.identifier.citationLangmuir 2024, 40, 29, 14838–14846. https://doi.org/10.1021/acs.langmuir.4c00642
dc.identifier.doi10.1021/acs.langmuir.4c00642
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/25500
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rightsUznanie autorstwa 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceLangmuir
dc.titleCopper Oxide Electrochemical Deposition to Create Antiviral and Antibacterial Nanocoatingsen
dc.typearticle
dc.type.versionpublishedVersion
person.identifier.orcidKusior, Anna [0000-0002-1730-7610]
person.identifier.orcidMazurkow, Julia [0000-0003-4035-1828]
person.identifier.orcidBik, Maciej [0000-0003-0921-8797]
person.identifier.orcidWdowiak, Mateusz [0000-0002-7822-9513]
person.identifier.orcidPaczesny, Jan [0000-0003-3758-3951]
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