Stressful Events and Serum Concentration of Substance P in Acne Patients

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dc.contributor.authorRokowska-Waluch, Anita
dc.contributor.authorPawlaczyk, Mariola
dc.contributor.authorCybulski, Marcin
dc.contributor.authorŻurawski, Jakub
dc.contributor.authorKaczmarek, Mariusz
dc.contributor.authorMichalak, Michał
dc.contributor.authorMojs, Ewa
dc.date.accessioned2016-10-12T08:26:27Z
dc.date.available2016-10-12T08:26:27Z
dc.date.issued2016
dc.description.abstractBackground: Psychological stress is an important factor of acne pathogenesis. Stress related production of hormones, cytokines and neuropeptides may result in the chronic course and exacerbations of the disease. Objective: The aim of the study was to evaluate the relationship between acne severity, intensity of emotional stress and serum concen tration of substance P (scSP), to compare the intensity of ad versities, psychological stress and scSP in acne patients with healthy controls and to compare coping techniques for stress. Methods: The study consisted of 80 patients. Emotio nal stress was analyzed with the use of social readjustment rating scale, whereas the methods of coping with stress were assessed with the coping inventory for stressful situation questionnaire. The blood concentration of substance P was analyzed by enzyme-linked immunosorbent assay method in a group of 40 patients with acne vulgaris and in control subjects. Results: There was no statistically significant differ ence between the severity of acne and the intensity of stress. Acne patients presented a higher average scSP than the controls. No statistically significant correlation was observed between the severity of acne and scSP; however, the in tensity of stress correlated with scSP in the control group. Theevaluation of methods of coping with stress showed sig nificantly higher rate for the avoidance-oriented coping among acne patients. Conclusion: The number of stressful events is not a factor that determines the severity of acne. The course of the disease may depend on tolerance to stress and methods of coping with stress. (Ann Dermatol 28(4) 464∼ 469, 2016)en
dc.description.epersonMarcin Cybulski
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/10547
dc.language.isoenpl_PL
dc.rightsDozwolony użytek
dc.subjectstresspl_PL
dc.subjectneuropeptidespl_PL
dc.subjectAcne vulgarispl_PL
dc.titleStressful Events and Serum Concentration of Substance P in Acne Patientspl_PL
dc.typearticlepl_PL
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