Evolutionary adaptation is facilitated by the presence of lethal genotypes

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dc.contributor.authorBlavatska, Victoria
dc.contributor.authorWaclaw, Bartlomiej
dc.contributor.organizationDioscuri Centre for Physics and Chemistry of Bacteria, Institute of Physical Chemistry, Warsaw, Polanden
dc.contributor.organizationSchool of Physics and Astronomy, The University of Edinburghen
dc.contributor.organizationInstitute for Condensed Matter Physics of the National Academy of Sciences of Ukraineen
dc.date.accessioned2024-04-02T10:28:26Z
dc.date.available2024-04-02T10:28:26Z
dc.date.issued2024-03
dc.descriptionFunding under Dioscuri, a programme initiated by the Max Planck Society, jointly managed with the National Science Centre in Poland, and mutually funded by Polish Ministry of Science and Higher Education and German Federal Ministry of Education and Research (UMO-2019/02/H/NZ6/00003) - U.S. National Academy of Sciences (NAS) and the Polish Academy of Sciences (PAS) programme for scientists from Ukraine.en
dc.description.abstractThe rate of adaptation in theoretical models of biological evolution generally increases with the mutation rate. However, there is a threshold beyond which mutations into lethal states lead to extinction. It would be logical to assume that eliminating such lethal states could be advantageous for evolution. Here we demonstrate that lethal mutations actually accelerate adaptation on rugged fitness landscapes with multiple peaks and valleys in the presence of competition for resources. We investigate a modified stochastic version of the quasispecies model, incorporating two types of genotypes-viable and lethal-and show that higher rates of lethal mutations result in shorter evolution times towards the best-fit genotype. This phenomenon can be attributed to an increased frequency of traversing fitness valleys, facilitated by reduced selection pressure against less-fit variants.en
dc.description.sponsorshipNCN, MPG, NAS, PAS
dc.identifier.citationV. Blavatska and B. Waclaw, Evolutionary Adaptation Is Facilitated by the Presence of Lethal Genotypes, Phys. Rev. Res. 6, 013286 (2024). https://doi.org/10.1103/PhysRevResearch.6.013286en
dc.identifier.doi10.1103/PhysRevResearch.6.013286
dc.identifier.issn2643-1564
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/24125
dc.language.isoen
dc.publisherAmerican Physical Societyen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleEvolutionary adaptation is facilitated by the presence of lethal genotypesen
dc.typearticleen
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