Hormonal profiles and the diagnostic utility of serum dihydrotestosterone in polycystic ovary syndrome: a comparative case-control study

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dc.contributor.authorHmoud, Taif Raheem
dc.contributor.authorJawad, Murtadha M.
dc.contributor.authorAlredha, Redha Dawud Abd
dc.contributor.organizationDepartment of Medical Laboratory Techniques, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Kufa, Iraq
dc.contributor.organizationCollege of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Kufa, Iraq
dc.contributor.organizationDepartment of Pathological Analysis Techniques, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, An Najaf, Iraq
dc.date.accessioned2026-01-23T12:10:13Z
dc.date.available2026-01-23T12:10:13Z
dc.date.issued2025-12-30
dc.date.submitted2026-01-19T15:20:32Zen
dc.description.abstractBackground: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hyperandrogenism, anovulation, and metabolic disturbances. Dihydrotestosterone (DHT), a potent androgen formed via the 5α-reductase pathway, may play a role in the clinical manifestations of PCOS. This study aimed to compare serum DHT levels in women with PCOS versus healthy controls and to evaluate its diagnostic value. Methods: In this case-control study, women aged 18-45 years were recruited from outpatient clinics at the Maysan Specialized Surgical Hospital (Al-Amarah, Iraq). PCOS was diagnosed according to the Rotterdam criteria, while age-matched healthy volunteers with regular menstrual cycles served as controls. All participants underwent comprehensive clinical assessments, including anthropometric measurements. Fasting venous blood samples were collected between 8:00 and 10:00 AM, and serum was isolated for biochemical analysis. Serum DHT concentrations were measured using a competitive ELISA. Statistical analyses, including group comparisons and receiver operating characteristic (ROC) curve analysis, were performed using IBM SPSS Statistics. Results: Participants with PCOS had significantly higher serum DHT levels (4256 ± 233 ng/L) compared to controls (3776 ± 186 ng/L, p < 0.001). ROC curve analysis identified an optimal DHT cutoff value of approximately 408.3 ng/L, yielding a sensitivity of 90% and specificity of 100% for PCOS diagnosis. Conclusion: Elevated serum DHT is a key feature of PCOS and demonstrates excellent diagnostic accuracy. These findings support the clinical utility of DHT as a reliable biomarker for early PCOS detection and may facilitate targeted therapeutic interventions.en
dc.identifier.citationHmoud T R, Jawad M M, Alredha R D. Hormonal profiles and the diagnostic utility of serum dihydrotestosterone in polycystic ovary syndrome: a comparative case-control study. Eur J Transl Clin Med. 2025;8(2):17-24. https://doi.org/10.31373/ejtcm/208403
dc.identifier.doi10.31373/ejtcm/208403
dc.identifier.issn2657-3156
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/26414
dc.language.isoen
dc.publisherMedical University of Gdańsk
dc.relation.ispartofseries8; 2
dc.rightsUznanie autorstwa-Na tych samych warunkach 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.sourceEuropean Journal of Translational and Clinical Medicine
dc.subjectpolycystic ovary syndrome (PCOS)en
dc.subjecthyperandrogenismen
dc.subjectdihydrotestosterone (DHT)en
dc.subject5α-reductaseen
dc.subjectdiagnostic biomarkeren
dc.titleHormonal profiles and the diagnostic utility of serum dihydrotestosterone in polycystic ovary syndrome: a comparative case-control studyen
dc.typearticle
dc.type.versionpublishedVersion
person.identifier.orcidJawad, Murtadha M. [0000-0002-7097-1270]
person.identifier.orcidAlredha, Redha Dawud Abd [0009-0005-6774-5036]
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