Meta-analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) genetic polymorphisms and Graves’ disease

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dc.contributor.authorKalarani, Iyshwarya Bhaskar
dc.contributor.authorVeerabathiran, Ramakrishnan
dc.contributor.organizationHuman Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, India
dc.date.accessioned2026-01-23T12:22:41Z
dc.date.available2026-01-23T12:22:41Z
dc.date.issued2025-12-30
dc.date.submitted2026-01-19T15:30:46Zen
dc.description.abstractBackground: Graves’ disease (GD) is an autoimmune disorder specific to the thyroid, characterized by a complex etiology influenced by both genetic and environmental factors. The CTLA-4 gene, known for its involvement in immune regulation, has been scrutinized regarding its potential contribution to GD susceptibility, particularly concerning the rs3087243 polymorphism. We conducted a meta-analysis to explore the association between this genetic variation and the likelihood of GD development. Methods: We thoroughly searched the PubMed, Medline, and EMBASE databases, as well as the reference lists of pertinent articles published up to 2024. Studies examining the association between GD and the CTLA-4 CT60 polymorphism were selected for inclusion. Data extraction and statistical analyses were conducted using Review Manager 5.4 software, which assessed multiple genetic models and the publication bias. Results: Six studies encompassing 1904 controls and 926 GD cases met the inclusion criteria. Our meta-analysis uncovered a substantial correlation between the CTLA-4 (rs3087243) polymorphism and GD across multiple genetic models (allele, homozygous, dominant, and recessive), suggesting the potential role of this genetic variant in predisposing individuals to GD. An examination of publication bias revealed symmetrical funnel plots. Conclusion: Our meta-analysis provides evidence for a significant association between GD and the CTLA-4 (rs3087243) polymorphism, highlighting its potential contribution to GD susceptibility. Additional investigation utilizing larger sample sizes and diverse populations is essential to corroborate these findings and clarify the exact mechanisms governing the association between the CTLA-4 gene and GD.en
dc.identifier.citationKalarani I B, Veerabathiran R. Meta-analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) genetic polymorphisms and Graves’ disease. Eur J Transl Clin Med. 2025;8(2):35-42. https://doi.org/10.31373/ejtcm/208803
dc.identifier.doi10.31373/ejtcm/208803
dc.identifier.issn2657-3156
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/26416
dc.language.isoen
dc.publisherMedical University of Gdańsk
dc.rightsUznanie autorstwa-Na tych samych warunkach 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.sourceEuropean Journal of Translational and Clinical Medicine
dc.subjectautoimmune thyroid diseaseen
dc.subjectGraves' diseaseen
dc.subjectpolymorphismen
dc.subjectrs3087243en
dc.subjectheterogeneityen
dc.titleMeta-analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) genetic polymorphisms and Graves’ diseaseen
dc.typearticle
dc.type.versionpublishedVersion
person.identifier.orcidKalarani, Iyshwarya Bhaskar [0000-0001-9368-3434]
person.identifier.orcidVeerabathiran, Ramakrishnan [0000-0002-9307-5428]
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