Interplay between cooperativity of intercellular receptor-ligand binding and coalescence of nanoscale lipid clusters in adhering membranes

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dc.contributor.authorLi, Long
dc.contributor.authorHu, Jingley
dc.contributor.authorShi, Xinghua
dc.contributor.authorRóżycki, Bartosz
dc.contributor.authorSong, Fan
dc.contributor.organizationState Key Laboratory of Nonlinear Mechanics and Beijing Key Laboratory of Engi- neered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, Chinaen
dc.contributor.organizationKuang Yaming Honors School and Institute for Brain Sciences, Nanjing University, Nanjing, Chinaen
dc.contributor.organizationNational Center for Nanoscience and Technology of China, Beijing, Chinaen
dc.contributor.organizationInstitute of Physics, Polish Academy of Sciencesen
dc.contributor.organizationSchool of Engineering Science, University of Chinese Academy of Sciences, Beijing, Chinaen
dc.date.accessioned2023-07-03T14:21:06Z
dc.date.available2023-07-03T14:21:06Z
dc.date.issued2020-12-22
dc.descriptionAccepted Manuscripten
dc.description.abstractAdhesion of biological cells is mediated by the specific binding of receptors and ligands which are typically large proteins spanning through the plasma membranes of the contacting cells. The receptors and ligands can exhibit affinity for nanoscale lipid clusters that form within the plasma membrane. A central question is how these nanoscale lipid clusters physically affect and respond to the receptor–ligand binding during cell adhesion. Within the framework of classical statistical mechanics we find that the receptor–ligand binding reduces the threshold energy for lipid clusters to coalesce into mesoscale domains by up to ∼50%, and that the formation of these domains induces significant cooperativity of the receptor–ligand binding. The interplay between the receptor–ligand binding cooperativity and the lipid domain formation manifests acute sensitivity of the membrane system to changes in control parameters. This sensitivity can be crucial in cell signaling and immune responses.en
dc.identifier.citationLong Li, Jinglei Hu, Xinghua Shi, Bartosz Rozycki, Fan Song, "Interplay between cooperativity of intercellular receptor-ligand binding and coalescence of nanoscale lipid clusters in adhering membranes", Soft Matter 17, 1912-1920 (2021). DOI: 10.1039/D0SM01904Fen
dc.identifier.doi10.1039/D0SM01904F
dc.identifier.issn1744-6848
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/22666
dc.language.isoen
dc.publisherRoyal Society of Chemistryen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleInterplay between cooperativity of intercellular receptor-ligand binding and coalescence of nanoscale lipid clusters in adhering membranesen
dc.typearticleen
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