Site-Selective, Photocatalytic Vinylogous Amidation of Enones

Szabó, Kitti Franciska; Goliszewska, Katarzyna; Szurmak, Jakub; Rybicka-Jasińska, Katarzyna; Gryko, Dorota

Site-Selective, Photocatalytic Vinylogous Amidation of Enones

dc.contributor.author	Szabó, Kitti Franciska
dc.contributor.author	Goliszewska, Katarzyna
dc.contributor.author	Szurmak, Jakub
dc.contributor.author	Rybicka-Jasińska, Katarzyna
dc.contributor.author	Gryko, Dorota
dc.contributor.organization	Institute of Organic Chemistry, Polish Academy of Sciences	en
dc.date.accessioned	2022-11-18T15:22:21Z
dc.date.available	2022-11-18T15:22:21Z
dc.date.issued	2022
dc.description.abstract	Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. The photocatalytic vinylogous reaction of dienolates with N-amino pyridinium salts affords γ-amido carbonyl compounds. This process is high-yielding, scalable, and tolerates a broad range of unsaturated α,β-unsaturated carbonyls, including biologically relevant compounds, as starting materials.	en
dc.description.sponsorship	National Science Center: MAESTRO UMO-2020/38/A/ST4/00185 and ETIUDA 7 UMO-2019/32/T/ST4/00303
dc.identifier.citation	Org. Lett. 2022, 24, 44, 8120–8124 ; https://doi.org/10.1021/acs.orglett.2c03161	en
dc.identifier.doi	10.1021/acs.orglett.2c03161
dc.identifier.issn	1523-7060
dc.identifier.issn	1523-7052
dc.identifier.uri	https://open.icm.edu.pl/handle/123456789/21871
dc.language.iso	en
dc.publisher	American Chemical Society	en
dc.rights	Uznanie autorstwa 4.0 Międzynarodowe	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.title	Site-Selective, Photocatalytic Vinylogous Amidation of Enones	en
dc.type	article	en