Urolithins and their possible implications for diabetic kidney

Kotewicz, Milena; Lewko, Barbara

Urolithins and their possible implications for diabetic kidney

dc.contributor.author	Kotewicz, Milena
dc.contributor.author	Lewko, Barbara
dc.contributor.organization	Department of Pharmaceutical Pathophysiology, Medical University of Gdańsk, Poland	en
dc.date.accessioned	2022-07-14T13:02:44Z
dc.date.available	2022-07-14T13:02:44Z
dc.date.issued	2022-02-21
dc.description.abstract	The increasing prevalence of diabetic kidney disease (DKD), a common complication of type 1 and type 2 diabetes, is becoming a leading risk factor of developing end stage renal disease (ESRD). The multiple mechanisms involved in renal tissue damage are a challenge for effective targeted therapy. Urolithins are metabolites generated by gut microbiota upon dietary intake of plant-derived ellagitannins. Multidirectional effects of these compounds include their anti-inflammatory, antioxidant, anti-proliferatory, anti-migratory and antiglycative properties that are mediated by modulation of signaling pathways and gene expression. Biochemical properties of urolithins indicate their capacity to regulate numerous mechanisms responsible for developing the hyperglycemia-induced tissue injury. The potentially beneficial effects of urolithins on podocytes, the most vulnerable renal cells should be particularly considered. The purpose of this review is to provide the evidence from the in vivo and in vitro studies showing that urolithin-based therapy could be a useful tool for protecting the kidneys from damage in diabetes.	en
dc.identifier.citation	Kotewicz M, Lewko B. Urolithins and their possible implications for diabetic kidney. Eur J Transl Clin Med. 2022;5(1):53-63. DOI: 10.31373/ejtcm/137918	en
dc.identifier.doi	10.31373/ejtcm/137918
dc.identifier.issn	2657-3156
dc.identifier.uri	https://open.icm.edu.pl/handle/123456789/21480
dc.language.iso	en
dc.publisher	Medical University of Gdańsk	en
dc.rights	Uznanie autorstwa-Na tych samych warunkach 4.0 Międzynarodowe	*
dc.rights.uri	http://creativecommons.org/licenses/by-sa/4.0/	*
dc.subject	urolithins	en
dc.subject	diabetes	en
dc.subject	kidney	en
dc.subject	podocytes	en
dc.title	Urolithins and their possible implications for diabetic kidney	en
dc.type	article	en