Light-Driven Regioselective Deoxygenation of Carbohydrate Lactones for 2-Deoxy Sugar Precursor Synthesis

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Authors
Najczuk, Justyna
Chaładaj, Wojciech ORCID logo 0000-0001-8143-3788
Furman, Bartłomiej ORCID logo 0000-0001-5459-8026
Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
License
Creative Commons License
Attribution 4.0 International
Abstract
A sustainable method for the synthesis of 2-deoxy lactones as direct precursors to 2-deoxy sugars via regioselective UV-light-driven dealkyloxylation of carbohydrate-derived lactones is detailed. This catalyst- and additive-free protocol utilizes light irradiation, providing high step economy and functional group compatibility. This environmentally friendly and straightforward approach enhances the synthetic toolbox for 2-deoxy sugars, which is vital in numerous biologically active molecules and drug candidates.
Description
Citation
Org. Lett. 2025, 27, 1221−1225 // https://doi.org/10.1021/acs.orglett.4c04763
URI
https://open.icm.edu.pl/handle/123456789/25965
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