Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

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dc.contributor.authorRozwadowska, Katarzyna
dc.contributor.authorDaniłowicz-Szymanowicz, Ludmiła
dc.contributor.authorFijałkowski, Marcin
dc.contributor.authorSikorska, Katarzyna
dc.contributor.authorSzymanowicz, Wiktor
dc.contributor.authorLewicka, Ewa Katarzyna
dc.contributor.authorRaczak, Grzegorz
dc.date.accessioned2019-08-20T10:09:23Z
dc.date.available2019-08-20T10:09:23Z
dc.date.issued2018-09
dc.description.abstractBackground: hereditary haemochromatosis (HH) is an inherited disease in which gene mutation leads to excessive iron absorption and accumulation in different organs, including the heart, which causes damage. Whether the age of patients with HH at the moment of their first diagnosis has an additional effect on the standard echocardiographic parameters was the aim of the study. Material and methods: we prospectively enrolled 20 HH patients, and 20 healthy age- and sex-matched volunteers. Analysis of standard echocardiographic parameters was performed and compared in subgroups of ≥50 and <50 years old (yo). Results: comparing HH patients with healthy volunteers in ≥50 yo subgroup, significant differences were found in parameters regarding diastolic function (IVS thickness, LVM index, Em, E/Em, PV S/D, LAA index and LAV index). In the <50 yo subgroup we did not find the abovementioned differences, however LVEF appeared to be lower in the HH patients. Conclusions: despite the lack of clinical symptoms of cardiovascular disease and the lack of deviations in the standard echocardiographic examination, there were a number of differences regarding LV diastolic function parameters in HH patients ≥50 yo, whereas differences regarding LV systolic function were more prominent in HH patients <50 yo when compared with healthy subjects.en
dc.identifier.citationRozwadowska K, Daniłowicz-Szymanowicz L, Fijałkowski M, Sikorska K, Szymanowicz W, et al. Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters? Eur J Transl Clin Med 2018;1(1):18-23.DOI: 10.31373/ejtcm/95222en
dc.identifier.doi10.31373/ejtcm/95222
dc.identifier.issn2657-3156
dc.identifier.urihttps://ejtcm.gumed.edu.pl/articles/11
dc.identifier.urihttps://depot.ceon.pl/handle/123456789/17199
dc.language.isoen
dc.publisherGdański Uniwersytet Medycznyen
dc.rightsUznanie autorstwa-Na tych samych warunkach 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/pl/*
dc.subjectageen
dc.subjectechocardiographyen
dc.subjecthereditary hemochromatosisen
dc.titleDoes the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?en
dc.typearticleen
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