Distinct characteristics of multisystem inflammatory syndrome in children in Poland

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dc.contributor.authorLudwikowska, Kamila Maria
dc.contributor.authorOkarska-Napierała, Magdalena
dc.contributor.authorDudek, Natalia
dc.contributor.authorTracewski, Paweł
dc.contributor.authorKusa, Jacek
dc.contributor.authorPiwoński, Krzysztof Piotr
dc.contributor.authorAfelt, Aneta
dc.contributor.authorCysewski, Dominik
dc.contributor.authorBiela, Mateusz
dc.contributor.authorWerner, Bożena
dc.contributor.authorJackowska, Teresa
dc.contributor.authorSuski-Grabowski, Catherine
dc.contributor.authorKursa, Miron Bartosz
dc.contributor.authorKuchar, Ernest
dc.contributor.authorSzenborn, Leszek
dc.contributor.organizationDepartment of Pediatric Infectious Diseases, Wroclaw Medical University, Polanden
dc.contributor.organizationDepartment of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Polanden
dc.contributor.organizationDepartment of Pediatric Cardiology, Research and Development Center, Regional Specialist Hospital in Wroclaw, Polanden
dc.contributor.organizationInterdisciplinary Centre for Mathematical and Computational Modelling, University of Warsawen
dc.contributor.organizationInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Polanden
dc.contributor.organizationDepartment of Paediatrics and Rare Disorders, Wroclaw Medical University, Polanden
dc.contributor.organizationDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Polanden
dc.date.accessioned2022-04-04T12:23:22Z
dc.date.available2022-04-04T12:23:22Z
dc.date.issued2021
dc.description.abstractDuring the winter months of 2020/2021 a wave of multisystem inflammatory syndrome in children (MIS-C) emerged in Poland. We present the results of a nationwide register aiming to capture and characterise MIS-C with a focus on severity determinants. The first MIS-C wave in Poland was notably high, hence our analysis involved 274 children. The group was 62.8% boys, with a median age of 8.8 years. Besides one Asian, all were White. Overall, the disease course was not as severe as in previous reports, however. Pediatric intensive care treatment was required for merely 23 (8.4%) of children, who were older and exhibited a distinguished clinical picture at hospital admission. We have also identified sex-dependent differences; teenage boys more often had cardiac involvement (decreased ejection fraction in 25.9% vs. 14.7%) and fulfilled macrophage activation syndrome definition (31.0% vs. 15.2%). Among all boys, those hospitalized in pediatric intensive care unit were significantly older (median 11.2 vs. 9.1 years). Henceforth, while ethnicity and sex may affect MIS-C phenotype, management protocols might be not universally applicable, and should rather be adjusted to the specific population.en
dc.identifier.citationLudwikowska, K.M., Okarska-Napierała, M., Dudek, N. et al. Distinct characteristics of multisystem inflammatory syndrome in children in Poland. Sci Rep 11, 23562 (2021). https://doi.org/10.1038/s41598-021-02669-2en
dc.identifier.doi10.1038/s41598-021-02669-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/21226
dc.language.isoen
dc.publisherSpringer Natureen
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmultisystem inflammatory syndrome in childrenen
dc.subjectMIS-Cen
dc.subjectSARS-CoV-2en
dc.subjectCOVID-19en
dc.subjectimmunological disordersen
dc.titleDistinct characteristics of multisystem inflammatory syndrome in children in Polanden
dc.typearticleen
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