Long-term deep phenotyping of behavioral traits in mice using homecage monitoring

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dc.contributor.authorJurek, Benjamin
dc.contributor.authorSchlegel, Patrick
dc.contributor.authorZglinicki, Bartosz
dc.contributor.authorAman, London
dc.contributor.authorKovarova, Veronika
dc.contributor.authorNarayan, Sowmya
dc.contributor.authorFlorea, Rebecca
dc.contributor.authorZiuzia, Patrycja
dc.contributor.authorBadura, Aleksandra
dc.contributor.authorSchmidt, Mathias V.
dc.contributor.authorŚlęzak, Michał
dc.contributor.organizationMax Planck Institute for Psychiatry, Neurobiology of Stress Resilience, Munich, Germany
dc.contributor.organizationMax Planck Institute for Psychiatry, Research Group Statistical Genetics, Munich, Germany
dc.contributor.organizationDepartment of Life Science and Biotechnology, Biology of Astrocytes Research Group, Lukasiewicz Research Network - PORT Polish Center for Technology Development, Wrocław, Poland
dc.contributor.organizationDepartment of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
dc.contributor.organizationDepartment of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
dc.contributor.organizationGraduate School of Systemic Neurosciences, Ludwig Maximilians University (GSN-LMU), Munich, Germany
dc.contributor.organizationLudwig Maximilians University (LMU) Munich, Faculty of Biology, Organismic Neurobiology, Munich, Germany
dc.date.accessioned2026-02-16T22:48:33Z
dc.date.available2026-02-16T22:48:33Z
dc.date.issued2025-11-02
dc.date.submitted2026-02-16T14:10:17Zen
dc.description.abstractNeuropsychiatric disorders represent a significant global health challenge, and a deeper understanding of their underlying neurobiology is urgently needed. Rodent models are indispensable in this pursuit, yet traditional behavioral phenotyping often relies on short-duration tests in artificial settings, raising concerns about ecological validity, stress confounds, and limited translational relevance. This paper begins by reviewing these limitations and highlighting the growing shift towards long-term, continuous monitoring of animals within their semi-naturalistic environment. Building on this context and the critical need for robust methodologies, this paper outlines a comprehensive workflow for studying behavior of rodent cohorts in their home cages using AI-supported video tracking. Key steps include the design of experimental setups, video preprocessing, animal tracking, pose estimation, supervised or unsupervised interpretation of behavior, statistical analysis and visualization. The protocol encompasses an affordable and versatile pipeline for data acquisition and statistical interpretation. Ultimately, this work aims to provide researchers with both a critical overview of the field and a practical guide to implementing these powerful techniques, thereby fostering the generation of reproducible, high-quality data to enhance the depth and translational potential of neuroscience and behavioral research.en
dc.identifier.citationBenjamin Jurek, Patrick Schlegel, Bartosz Zglinicki, London Aman, Veronika Kovarova, Sowmya Narayan, Rebecca Florea, Patrycja Ziuzia, Aleksandra Badura, Mathias V Schmidt, Michal Slezak, Long-term deep phenotyping of behavioral traits in mice using homecage monitoring, Neuroscience & Biobehavioral Reviews, Volume 180, 2026, 106453
dc.identifier.doi10.1016/j.neubiorev.2025.106453
dc.identifier.issn0149-7634
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/26519
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofseriesVolume 180; 106453
dc.rightsUznanie autorstwa 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceNeuroscience & Biobehavioral Reviews
dc.subjectdeep phenotypingen
dc.subjectcomplex behavioren
dc.subjecthomecage monitoringen
dc.subjectlong-term recordingen
dc.subjectmachine-learningen
dc.subjectAIen
dc.subjectpose estimationen
dc.subjectdynamic analysisen
dc.subjectautomatizationen
dc.subjectreproducibilityen
dc.subject3 Ren
dc.subjectneuropsychiatric symptomsen
dc.titleLong-term deep phenotyping of behavioral traits in mice using homecage monitoringen
dc.typearticle
person.identifier.orcidŚlęzak, Michał [0000-0003-2224-3989]
person.identifier.orcidJurek, Benjamin [0000-0001-7124-510X]
person.identifier.orcidAman, London [0000-0002-5284-2926]
person.identifier.orcidZiuzia, Patrycja [0009-0007-8932-6507]
person.identifier.orcidBadura, Aleksandra [0000-0002-0119-5108]
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