Electrochemically Synthesized Polyacrylamide Gel and Core−Shell Nanoparticles for 3D Cell Culture Formation

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Authors
Yasmeen, Nabila
Karpinska, Aneta
Kalecki, Jakub
Kutner, Wlodzimierz
Kwapiszewska, Karina
Sharma, Piyush Sindhu
Date
2022-07-17
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
License
Creative Commons License
Attribution 4.0 International
Abstract
Biocompatible polyacrylamide gel and core−shell nanoparticles (NPs) were synthesized using a one-step electrochemically initiated gelation. Constant-potential electrochemical decomposing of ammonium persulfate initiated the copolymerization of N-isopropyl acrylamide, methacrylic acid, and N,N′-methylenebisacrylamide monomers. This decomposing potential and monomers’ concentrations were optimized to prepare gel NPs and thin gel film-grafted core−shell NPs. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) imaging confirmed the gel NP formation. The lyophilized gel NPs and core−shell NPs were applied to support the three-dimensional (3D) cell culture. In all, core−shell NPs provided superior support for complex 3D tissue structures.
Description
Keywords
electrochemically initiated persulfate decomposition  polyacrylamide gel  nanogel  core−shell nanogel  biocompatible gel  3D cell culture
Citation
ACS Appl. Mater. Interfaces 2022, 14, 32836−32844. https://doi.org/10.1021/acsami.2c04904
URI
https://open.icm.edu.pl/handle/123456789/21557
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