Imaging of retinal ganglion cells and photoreceptors using Spatio-Temporal Optical Coherence Tomography (STOC-T) without hardware-based adaptive optics
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0000-0002-4451-2492 Date
2025-01-15
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We demonstrate an experimental Spatio-Temporal Optical Coherence Tomography (STOC-T) system featuring optimized illumination and an increased lateral resolution of approximately 3 μm. The integration of high-speed phase randomization with a numerical averaging process facilitates a noticeable improvement in the signal-tonoise ratio. The effectiveness of this enhancement is demonstrated through volumetric imaging of a scattering object, and it enables in vivo imaging of the human retina at the cellular level. Additionally, the experiment is supported by computational aberration-correction techniques to achieve high-resolution in vivo imaging of the human retina. The visualization of retinal cone mosaics, and ganglion cell somas was achieved through contrast enhancement during the averaging process.
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Marta Mikuła-Zdańkowska, Dawid Borycki, Piotr Węgrzyn, Karolis Adomavičius, Egidijus Auksorius, Maciej Wojtkowski, Imaging of retinal ganglion cells and photoreceptors using Spatio-Temporal Optical Coherence Tomography (STOC-T) without hardware-based adaptive optics, Biocybernetics and Biomedical Engineering, 45, 52-61, (2025). https://doi.org/10.1016/j.bbe.2025.01.001