Medication errors in anti-retroviral therapy among people living with HIV and the impact of stewardship interventions: study protocol for a systematic review and meta-analysis
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EJTCM_2026_9_1_David.pdf (383.89 KB)
0000-0002-3796-8934 Date
2026-07-06
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Medical University of Gdańsk
Abstract
Background: Medication errors involving antiretroviral therapy (ART) in people living with HIV (PLHIV) are frequent, particularly in general hospitals and during care transitions, and may lead to preventable toxicity, virological failure and drug resistance. Several stewardship interventions have been implemented to reduce these errors, but the available evidence remains fragmented and heterogeneous. Material and methods: We will conduct a systematic review and meta-analysis of observational studies and intervention studies reporting ART-related medication errors in adults (≥ 18 years) with HIV in any clinical setting. We will search MEDLINE, Embase, CINAHL, Web of Science, CENTRAL and grey literature without language or date restrictions. Two reviewers will independently screen records, extract data and assess risk of bias using design-specific tools (RoB-2, ROBINS-I, Newcastle-Ottawa Scale and EPOC). We will perform random-effects meta-analyses when appropriate and synthesize implementation outcomes narratively. Certainty of evidence for key outcomes will be assessed with GRADE. Conclusions: This review will provide up-to-date, quantitatively synthesized estimates of the burden and clinical impact of ART-related medication errors and will evaluate the effectiveness of antiretroviral stewardship and related interventions. Its findings will inform HIV units, antimicrobial stewardship programmes and policy-makers aiming to improve the safety of ART. Study registration: PROSPERO CRD420251233303.
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David C d, Mateo-González J I. Medication errors in anti-retroviral therapy among people living with HIV and the impact of stewardship interventions: study protocol for a systematic review and meta-analysis. Eur J Transl Clin Med. 2026;9(1):87-92