PEGylated Network Nanostructured by Gold Nanoparticles for Electrochemical Sensing of Aromatic Redox and Nonredox Analytes

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dc.contributor.authorSwiech, Olga
dc.contributor.authorMajdecki, Maciej
dc.contributor.authorBilewicz, Renata
dc.contributor.organizationFaculty of Chemistry, University of Warsaw
dc.contributor.organizationInstitute of Organic Chemistry, Polish Academy of Science
dc.date.accessioned2024-09-02T11:17:36Z
dc.date.available2024-09-02T11:17:36Z
dc.date.issued2024
dc.description.abstractWe present the design, tailoring, and physicochemical properties of a multicomponent polyethylene glycol (PEG)-based polymer doped with spherical nanoparticles modified with a lipoic acid derivative of cyclodextrin and its application for the electrochemical sensing of a ferrocene derivative and ibuprofen at low concentrations. Each of the components of this hybrid material has specific properties that can be useful for the preparation of sensors characterized by high selectivity and a low detection limit. Electrochemical studies have previously shown that the cyclodextrin derivative with an aromatic triazole linker in the structure enhances binding of the analyte, ensuring its preconcentration on the electrode and, therefore, enabling improvement of the sensor detection limit. On the other hand, the introduction of evenly dispersed spherical gold nanoparticles in the polymer matrix increases the conductivity of the film and enhances the analytical signal. The third component─a biocompatible and easily wettable cross-linker, PEG─allows for uninterrupted diffusion within the polymer film. This significantly increases the analytical performance of the sensor, supports further improvement of the detection limit, and enables the determination of the analyte after saturation of cyclodextrin cavities (high concentration of analyte) based on its diffusion response. The designed hybrid material was used for the direct and indirect determination of aromatic analytes─ferrocene derivative and ibuprofen─with a very low detection limit.en
dc.description.sponsorshipPolish National Science Center, project No. 2021/43/B/ST4/00533; Polish National Science Center, project No. 2011/01/N/ST5/05550
dc.identifier.citationACS Appl. Polym. Mater. 2023, 5, 214−222 ; https://doi.org/10.1021/acsapm.2c01451
dc.identifier.doi10.1021/acsapm.2c01451
dc.identifier.issn2637-6105
dc.identifier.urihttps://open.icm.edu.pl/handle/123456789/24794
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rightsUznanie autorstwa 4.0 Międzynarodoween
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceACS Applied Polymer Materials
dc.subjectibuprofenen
dc.subjectferroceneen
dc.subjectelectrochemical sensoren
dc.subjectcyclodextrinen
dc.subjectlipoic aciden
dc.subjectgold nanoparticlesen
dc.subjectinclusion complexen
dc.titlePEGylated Network Nanostructured by Gold Nanoparticles for Electrochemical Sensing of Aromatic Redox and Nonredox Analytesen
dc.typearticle
dc.type.versionpublishedVersion
person.identifier.orcidMajdecki, Maciej [0000-0002-4456-7944]
person.identifier.orcidSwiech, Olga [0000-0003-3322-2497]
person.identifier.orcidBilewicz, Renata [0000-0003-0058-3691]
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